Ammonia → 3-[(2-fluorobenzyl)oxy]-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxamide

HRID 2391606노트

반응식

HRID 2391606 반응식
[F:1][C:2]1[CH:27]=[CH:26][CH:25]=[CH:24][C:3]=1[CH2:4][O:5][C:6]1[CH:10]=[C:9]([N:11]2[C:19]3[CH:18]=[CH:17][N:16]=[CH:15][C:14]=3[N:13]=[CH:12]2)[S:8][C:7]=1[C:20]([O:22]C)=O.[NH3:28]>CO>[F:1][C:2]1[CH:27]=[CH:26][CH:25]=[CH:24][C:3]=1[CH2:4][O:5][C:6]1[CH:10]=[C:9]([N:11]2[C:19]3[CH:18]=[CH:17][N:16]=[CH:15][C:14]=3[N:13]=[CH:12]2)[S:8][C:7]=1[C:20]([NH2:28])=[O:22]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 68765200methyl 3-[(2-fluorobenzyl)oxy]-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylate

생성물 1

HCID 687681693-[(2-fluorobenzyl)oxy]-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxamide

시약·촉매·용매 1

HCID 887Methanol용매

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온도
125 °C

실험 절차

A mixture of 50 mg of methyl 3-[(2-fluorobenzyl)oxy]-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylate and 15 ml of a saturated solution of ammonia in methanol is stirred in a microwave vial at 125° C. for 4 h in the microwave cavity. The reaction mixture is concentrated to dryness, the resulting residue is recrystallized from 5 ml ethanol to yield the title compound.

후처리

  1. concentrationThe reaction mixture is concentrated to dryness
  2. customthe resulting residue is recrystallized from 5 ml ethanol

출처 및 근거

ORD 기록
ord-64b4451fa0cb4688866044cc756106e6
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08273890B2

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