Formic Acid → HCID 21683295, 화합물

반응식

Cl.Cl.[CH3:3][O:4][C:5]1[N:10]=[C:9]([NH2:11])[C:8]([NH2:12])=[CH:7][CH:6]=1.[CH:13](O)=O>>[CH3:3][O:4][C:5]1[N:10]=[C:9]2[N:11]=[CH:13][NH:12][C:8]2=[CH:7][CH:6]=1

참가 물질

반응물 2

HCID 284Formic Acid

HCID 30239192,3-Diamino-6-methoxypyridine dihydrochloride

생성물 1

HCID 21683295HCID 21683295, 화합물

실험 절차

10.19 g of 6-methoxypyridine-2,3-diamine dihydrochloride were dissolved in 100 ml formic acid and stirred under reflux for 72 h. The formic acid was evaporated under vacuum and the residue was dried under vacuum at 95° C. to give crude 5-methoxy-1H-imidazo[4,5-b]pyridine (as hydrochloride and/or as formic acid salt and/or as free base) that was used for the following step without further purification.

후처리

temperatureunder reflux for 72 h
customThe formic acid was evaporated under vacuum
customthe residue was dried under vacuum at 95° C.

출처 및 근거

ORD 기록: ord-861b197e53da4238a76a9264b8651928
출처 데이터셋: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08273890B2

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