Nitric Acid → 2,6-Dibromo-3-methoxy-5-nitropyridine
반응식
[N+:1]([O-:4])(O)=[O:2].[Br:5][C:6]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]([Br:14])[N:7]=1>S(=O)(=O)(O)O>[Br:5][C:6]1[C:11]([O:12][CH3:13])=[CH:10][C:9]([N+:1]([O-:4])=[O:2])=[C:8]([Br:14])[N:7]=1참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
To 150 ml of concentrated sulfuric acid were added at 0° C. 150 ml fuming nitric acid. 40.0 g of 2,6-dibromo-3-methoxypyridine (example E2) were added portionwise to this mixture at 0° C. The reaction mixture was stirred for 45 minutes at 0° C. and then heated to 65° C. for 2 h. The mixture was poured into 2 l of crushed ice and stored at 0° C. overnight. The resulting precipitate was filtered, washed with water and dried under vacuum to yield the title compound.
후처리
- temperatureheated to 65° C. for 2 h
- waitstored at 0° C. overnight
- filtrationThe resulting precipitate was filtered
- washwashed with water
- customdried under vacuum
출처 및 근거
- ORD 기록
- ord-29832a3e2df74f73985855f5b8eb8b9b
- 출처 데이터셋
- uspto-grants-2012_09
- 특허 번호
- US08273890B2
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