Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(Methoxycarbonylsulfamoyl)triethylammonium hydroxide → Benzyl 2-methyl-4,5,7,8-tetrahydrooxazolo[4,5-d]azepine-6-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (Methoxycarbonylsulfamoyl)triethylammonium hydroxide | HCID 11032497 | — |
| 반응물 | 4-Acetylamino-5-oxo-azepane-1-carboxylic acid benzyl ester | HCID 86686082 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Benzyl 2-methyl-4,5,7,8-tetrahydrooxazolo[4,5-d]azepine-6-carboxylate | HCID 86686083 | 814.9% |
반응 단계
3 g 4-acetylamino-5-oxo-azepane-1-carboxylic acid benzyl ester in 100 mL tetrahydrofuran and 3.8 g (methoxycarbonylsulfamoyl)triethylammonium hydroxide were heated in a sealed tube at 75° C. for 1 h. The solvent was evaporated and the residue was purified by chromatographie on silica gel (ethyl acetate/hexane 1:2) to yield 23 g of the desired product. (M+H)+: 287
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08642774B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-70918a54ec1b45ceb69878ad78586d14 |
| 출처 메모 | uspto-grants-2014_02 |