Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,6-Dimethylphenylboronic acid → 8-(2,6-Dimethyl-phenyl)-Quinoxaline-5-carboxylic acid [3-(4-ethyl-piperazin-1-yl)phenyl]-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,6-Dimethylphenylboronic acid | HCID 583322 | — |
| 반응물 | 3-(4-Ethylpiperazin-1-yl)aniline | HCID 22330105 | — |
| 반응물 | 8-(2,6-Dimethyl-phenyl)quinoxaline-5-carboxylic acid | HCID 66914574 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 생성물 | 8-(2,6-Dimethyl-phenyl)-Quinoxaline-5-carboxylic acid [3-(4-ethyl-piperazin-1-yl)phenyl]-amide | HCID 44516604 | — |
반응 단계
The title compound was prepared in analogy to the procedure described in Step 14.1 but using 3-(4-ethylpiperazin-1-yl)aniline (Step 2.1) and 8-(2,6-dimethyl-phenyl)-quinoxaline-5-carboxylic acid. The carboxylic acid was synthesized as described in Steps 1.2-1.7 but using 2,6-dimethylphenylboronic acid and Pd(PPh3)4 in Step 1.4. Title compound: ESI-MS: 466.2 [M+H]+; tR=3.74 min (System 3).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08273882B2 |
| 출처 데이터셋 | uspto-grants-2012_09 |
| ORD ID | ord-2f6ef2f9a29544b391d55990236db5cf |
| 출처 메모 | uspto-grants-2012_09 |