Thionyl Chloride → (3,5-bis-(4-Fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl chloride

HRID 239187노트

반응식

HRID 239187 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[N:10]([CH2:20][C:21]([OH:23])=O)[N:9]=2)=[CH:4][CH:3]=1.S(Cl)([Cl:26])=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[N:10]([CH2:20][C:21]([Cl:26])=[O:23])[N:9]=2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 86686517(3,5-bis-(4-Fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetic acid

생성물 1

HCID 86686520(3,5-bis-(4-Fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl chloride

실험 절차

1.2 g of ((3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetic acid in 15 mL thionylchloride was stirred 30 min. at 60° C. The solvent was removed to give 1.3 g desired product. (M+H)+: 334

후처리

  1. customThe solvent was removed

출처 및 근거

ORD 기록
ord-66624de0548e4e64a7544488cad39f19
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642774B2

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