참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Trimethylaluminum | HCID 16682925 | — |
| 반응물 | 5-(2,2,4-Trimethyl-piperazin-1-ylmethyl)-pyridin-2-ylamine | HCID 66914602 | — |
| 반응물 | 8-(2,6-Difluoro-3,5-dimethoxyphenyl)quinoxaline-5-carboxylic acid ethyl ester | HCID 86641145 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | HCID 59292957 | HCID 59292957 | — |
반응 단계
The title compound was prepared in analogy to the procedures described in Example 115 but using 8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester (Step 124.1), 5-(2,2,4-trimethyl-piperazin-1-ylmethyl)-pyridin-2-ylamine (Step 110.1), 1.5 equiv of trimethyl aluminum, stirring the reaction mixture for 6 h at 80° C. and pouring it onto a saturated aqueous solution of NaHCO3 and DCM. Title compound: ESI-MS: 563.1 [M+H]+; tR=3.55 min (System 1); TLC: Rf=0.08 (DCM/MeOH, 95:5).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08273882B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_09 |
|---|
| ORD ID | ord-c22f33710e854798a74732b77ac230cf |
|---|
| 출처 메모 | uspto-grants-2012_09 |
|---|
