Diethyl[2-(4-nitrophenoxy)ethyl]amine → 4-(2-(Diethylamino)ethoxy)aniline

HRID 23920노트

반응식

HRID 23920 반응식
[CH2:1]([N:3]([CH2:16][CH3:17])[CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][CH:8]=1)[CH3:2]>[Pd].C(O)C>[CH2:16]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([NH2:13])=[CH:11][CH:12]=1)[CH3:17]

참가 물질

4

반응물 1

HCID 88294Diethyl[2-(4-nitrophenoxy)ethyl]amine

생성물 1

HCID 4189324-(2-(Diethylamino)ethoxy)aniline수율 46%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 4-(2-diethylaminoethoxy)-1-nitrobenzene (Method 10) (1.0 g, 4.2 mmol) and 10% palladium on charcoal catalyst (200 mg) in ethanol (30 ml) was stirred under an atmosphere of hydrogen for 3 hours. The catalyst was removed by filtration through diatomaceous earth and the filter pad was washed with methanol. The volatiles were removed from the filtrate by evaporation to give the title compound (400 mg, 46%) as an oil. M/z: 209 [MH]+.

후처리

  1. customThe catalyst was removed by filtration through diatomaceous earth
  2. washthe filter pad was washed with methanol
  3. customThe volatiles were removed from the filtrate by evaporation

출처 및 근거

ORD 기록
ord-e9850bf8f4614397a428caf3690d3eee
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855719B1

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