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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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HCID 59611073, 화합물 → (S)-benzyl 2-amino-4-(difluoromethoxy)butanoate

HRID 2392445
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인쇄 미리보기

반응식

HRID 2392445 반응식
C(OC([NH:8][C@@H:9]([CH2:20][CH2:21][O:22][CH:23]([F:25])[F:24])[C:10]([O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:11])=O)(C)(C)C>C(O)(C(F)(F)F)=O.ClCCl>[NH2:8][C@@H:9]([CH2:20][CH2:21][O:22][CH:23]([F:24])[F:25])[C:10]([O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:11]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 1

HCID 59611073HCID 59611073, 화합물

생성물 1

HCID 67991507(S)-benzyl 2-amino-4-(difluoromethoxy)butanoate

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 6422Trifluoroacetic acid용매

실험 절차

(S)-benzyl 2-(tert-butoxycarbonylamino)-4-(difluoromethoxy)butanoate (161 mg, 0.448 mmol) was stirred in 30% TFA in dichloromethane (5 mL) for 1 h. The resulting mixture was concentrated down on rotovap and redissolved and concentrated down with toluene three times, and finally the residue was dried on high vacuum pump. The desired product was used as-is in the next step.

후처리

  1. concentrationThe resulting mixture was concentrated down on rotovap
  2. dissolutionredissolved
  3. concentrationconcentrated down with toluene three times
  4. customfinally the residue was dried on high vacuum pump

출처 및 근거

ORD 기록
ord-d15beddb333e425aa38802c1425fb7b1
출처 데이터셋
uspto-grants-2012_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08273341B2

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