Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(S)-Benzyl 2-amino-3-(4-hydroxyphenyl)propanoate → N-[2-acetylthiomethyl-3-(4-hydroxyphenyl)-1-oxobutyl]tyrosine benzyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (S)-Benzyl 2-amino-3-(4-hydroxyphenyl)propanoate | HCID 104541 | — |
| 반응물 | 2-Acetylthiomethyl-3-(4-hydroxyphenyl)butanoic acid | HCID 18980788 | — |
| 생성물 | N-[2-acetylthiomethyl-3-(4-hydroxyphenyl)-1-oxobutyl]tyrosine benzyl ester | HCID 10075398 | 78% |
반응 단계
Using the procedure described in Example 60, but starting with 2-acetylthiomethyl-3-(4-hydroxyphenyl)butanoic acid and tyrosine benzyl ester, N-[2-acetylthiomethyl-3-(4-hydroxyphenyl)-1-oxobutyl]tyrosine benzyl ester is obtained in a 78% yield in the form of a white solid, having the following characteristics: Rf =0.16 [hexane/ethyl acetate (65:35 by volume)].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05801274 |
| 출처 데이터셋 | uspto-grants-1998_09 |
| ORD ID | ord-a0498eba4daa4d7b8e491eda8464d61e |
| 출처 메모 | uspto-grants-1998_09 |