Bromine → 5-Bromo-8-methoxy-2-methylquinoline

HRID 2393084노트

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HRID 2393084 반응식
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[C:10]([CH3:13])[CH:9]=[CH:8]2.[Br:14]Br>CO>[Br:14][C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[C:12]2[C:7]=1[CH:8]=[CH:9][C:10]([CH3:13])=[N:11]2

참가 물질

4

반응물 2

HCID 24408BromineHCID 3169868-Methoxy-2-Methylquinoline

생성물 1

HCID 47150215-Bromo-8-methoxy-2-methylquinoline

시약·촉매·용매 1

HCID 887Methanol용매

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온도
45 °C

실험 절차

A solution of 8-methoxy-2-methylquinoline (1.0 g) in methanol (30 ml) was treated at room temperature with bromine (0.31 ml). The mixture was heated at 45° C. for 2 hours and the reaction quenched with 5% aqueous sodium metabisulphite (50 ml). The solution was basified with 25% aqueous sodium hydroxide to pH13 and the product extracted with ethyl acetate (2×100 ml). The extracts were combined, dried over magnesium sulphate, filtered and the filtrate evaporated in vacuo. The residue was dissolved in ethyl acetate and passed through a silica pad. The solution was evaporated in vacuo to yield the desired product as an off-white solid (0.43 g).

후처리

  1. customthe reaction quenched with 5% aqueous sodium metabisulphite (50 ml)
  2. extractionthe product extracted with ethyl acetate (2×100 ml)
  3. dry with materialdried over magnesium sulphate
  4. filtrationfiltered
  5. customthe filtrate evaporated in vacuo
  6. dissolutionThe residue was dissolved in ethyl acetate
  7. customThe solution was evaporated in vacuo

출처 및 근거

ORD 기록
ord-f7019cba75f449349a0c7c8c68bde685
출처 데이터셋
uspto-grants-1998_09
특허 번호
US05804588

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