Methanol → Methyl 3-(1,2-benzisoxazol-3-yl)propionate

반응식

[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11][C:12]#N)=[N:2]1.CC[O:16][CH2:17]C.C[OH:20]>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11][C:12]([O:16][CH3:17])=[O:20])=[N:2]1

참가 물질

반응물 3

HCID 887Methanol

HCID 3283Diethyl Ether

HCID 1227915159899-56-8

생성물 1

HCID 22012185Methyl 3-(1,2-benzisoxazol-3-yl)propionate

실험 절차

The nitrile was dissolved in methanol (200 ml) and HCI-saturated ether (200 ml) was added followed by stirring for 16 h at room temperature. The reaction mixture was concentrated in vacuo, water and ether added, and the phases separated. Drying of the ether phase over magnesium sulfate and removal of solvent in vacuo gave methyl 3-(1,2-benzisoxazol-3-yl)propionate (13 g) as an oil.

후처리

concentrationThe reaction mixture was concentrated in vacuo, water and ether
additionadded
customthe phases separated
dry with materialDrying of the ether phase over magnesium sulfate and removal of solvent in vacuo

출처 및 근거

ORD 기록: ord-1fe95c5ef52b4167b23aeae7c40ee946
출처 데이터셋: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05807871

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