Methyl 1-benzothiophene-3-carboxylate → 1-Benzothiophen-3-ylmethanol
반응식
[S:1]1[CH:5]=[C:4]([C:6](OC)=[O:7])[C:3]2[CH:10]=[CH:11][CH:12]=[CH:13][C:2]1=2.[H-].[Al+3].[Li+].[H-].[H-].[H-]>CCOCC>[S:1]1[CH:5]=[C:4]([CH2:6][OH:7])[C:3]2[CH:10]=[CH:11][CH:12]=[CH:13][C:2]1=2참가 물질
4
실험 절차
An ether solution (50 ml) of methyl benzo[b]thiophene-3-carboxylate (15 g) was added dropwise to a suspension of lithium aluminium hydride (3.5 g) in ether (100 ml) followed by reflux for 2 h. Usual work-up gave benzo[b]thiophen-3-yl methanol (13.5 g) as an oil.
후처리
- temperatureby reflux for 2 h
출처 및 근거
- ORD 기록
- ord-e8e4a27c8cc549c3bce2feb7b117d673
- 출처 데이터셋
- uspto-grants-1998_09
- 특허 번호
- US05807871
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