Dimethylformamide → 2-(1-Chloroethyl)-9H-fluorene

HRID 2393500노트

반응식

HRID 2393500 반응식
S(Cl)([Cl:3])=O.CN(C)C=O.O[CH:11]([C:13]1[CH:25]=[CH:24][C:23]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:16][C:15]=2[CH:14]=1)[CH3:12]>C(Cl)Cl>[Cl:3][CH:11]([C:13]1[CH:25]=[CH:24][C:23]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:16][C:15]=2[CH:14]=1)[CH3:12]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 26584520371-86-2

생성물 1

HCID 145724842-(1-Chloroethyl)-9H-fluorene

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Thionyl chloride (1.1 ml) and catalytically effective amount of N,N-dimethylformamide were added to a solution of 2-(1-hydroxyethyl)-9H-fluorene (1.05 g) in methylene chloride (15 ml) under ice-cooling, and the mixture was stirred at room temperature for 30 minutes and then heated under reflux for 1 hour. By evaporating the solvent under reduced pressure, 2-(1-chloroethyl)-9H-fluorene was obtained.

후처리

  1. temperaturecooling
  2. temperatureheated
  3. temperatureunder reflux for 1 hour
  4. customBy evaporating the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-07ed4ea18b1a4fd9b1ae585a97fa8fbf
출처 데이터셋
uspto-grants-1998_09
특허 번호
US05807880

반응 노트

불러오는 중…