Sodium Methoxide → 5-(Methoxymethyl)quinolin-8-ol

HRID 23937

반응식

HRID 23937 반응식
Cl.Cl[CH2:3][C:4]1[CH:13]=[CH:12][C:11]([OH:14])=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[N:9]2.[CH3:15][O-:16].[Na+]>CO>[CH3:15][O:16][CH2:3][C:4]1[CH:13]=[CH:12][C:11]([OH:14])=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[N:9]2

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 122695968-Quinolinol, 5-(chloromethyl)-, hydrochloride (1:1)

생성물 1

HCID 6901295-(Methoxymethyl)quinolin-8-ol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

5-Chloromethyl-8-hydroxyquinoline hydrochloride (2.145 g; 9.3 mmol) was added to a mixture of sodium methoxide (1.763 g; 32.6 mmol) in MeOH (40 ml). The reaction mixture was stirred for about 4 h at room temperature, and then evaporated to dryness. The residue was dissolved in CHCl3 (100 ml, the solution was washed with water until a neutral pH was obtained, and was then washed with brine, dried over Na2SO4 and evaporated to dryness. The residue was extracted with hexane (100 ml). The hexane solution was evaporated to give the title product, 0.36 g (20%). M.p. 75-760° C. TLC (CHCl3/MeOH/NH3.9.5:0.5:0.1). Rf=0.36.

후처리

  1. customevaporated to dryness
  2. dissolutionThe residue was dissolved in CHCl3 (100 ml
  3. washthe solution was washed with water until a neutral pH
  4. customwas obtained
  5. washwas then washed with brine
  6. dry with materialdried over Na2SO4
  7. customevaporated to dryness
  8. extractionThe residue was extracted with hexane (100 ml)
  9. customThe hexane solution was evaporated

출처 및 근거

ORD 기록
ord-2ec5d463dceb4791969bf473db271151
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855711B1

연결된 노트

불러오는 중…