(1S,6S)-2,8-Diazabicyclo(4.3.0)nonane → HCID 18665331, 화합물

HRID 2394304노트

반응식

HRID 2394304 반응식
Cl[C:2]1[C:11]([Cl:12])=[C:10]2[C:5]([C:6](=[O:19])[C:7]([C:16]([OH:18])=[O:17])=[CH:8][N:9]2[CH:13]2[CH2:15][CH2:14]2)=[CH:4][N:3]=1.[C@@H:20]12[CH2:28][NH:27][CH2:26][C@@H:25]1[CH2:24][CH2:23][CH2:22][NH:21]2>CN(C)C=O.C(#N)C>[Cl:12][C:11]1[C:2]([N:27]2[CH2:28][C@@H:20]3[C@@H:25]([CH2:24][CH2:23][CH2:22][NH:21]3)[CH2:26]2)=[N:3][CH:4]=[C:5]2[C:10]=1[N:9]([CH:13]1[CH2:15][CH2:14]1)[CH:8]=[C:7]([C:16]([OH:18])=[O:17])[C:6]2=[O:19]

참가 물질

5

반응물 2

HCID 10313138(1S,6S)-2,8-Diazabicyclo(4.3.0)nonaneHCID 189731217,8-Dichloro-1-cyclopropyl-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylic acid

생성물 1

HCID 18665331HCID 18665331, 화합물

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 6342Acetonitrile용매

실험 절차

200 mg (0.67 mmol) of 7,8-dichloro-1-cyclopropyl-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylic acid are stirred with 190 mg (1.5 mmol) of (1S,6S)-2,8-diazabicyclo[4.3.0]nonane in a mixture of 1.7 ml of dimethylformamide and 1.7 ml of acetonitrile under argon overnight. The precipitate is isolated and washed with acetonitrile. The crude product is purified on silica gel (eluent: dichloromethane/methanol/aqueous ammonia solution 75:20:25).

후처리

  1. customThe precipitate is isolated
  2. washwashed with acetonitrile
  3. customThe crude product is purified on silica gel (eluent: dichloromethane/methanol/aqueous ammonia solution 75:20:25)

출처 및 근거

ORD 기록
ord-3937b85528af4856a326fae06cced6c6
출처 데이터셋
uspto-grants-1998_09
특허 번호
US05811433

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