Indole-4-carboxaldehyde → 1-(2-Thienylmethyl)indole-4-carbaldehyde

반응식

[NH:1]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([CH:10]=[O:11])[C:4]=2[CH:3]=[CH:2]1.CS(O[CH2:17][C:18]1[S:19][CH:20]=[CH:21][CH:22]=1)(=O)=O>>[S:19]1[CH:20]=[CH:21][CH:22]=[C:18]1[CH2:17][N:1]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([CH:10]=[O:11])[C:4]=2[CH:3]=[CH:2]1

참가 물질

반응물 2

HCID 333703Indole-4-carboxaldehyde

HCID 189734302-Thienylmethyl methanesulfonate

생성물 1

HCID 189733511-(2-Thienylmethyl)indole-4-carbaldehyde

실험 절차

The same procedures used in Example 1 were repeated except for using 725 mg of indole-4-carbaldehyde and 2-thienylmethyl methanesulfonate instead of the benzyl bromide used in Example 1 to give 392 mg of 1-(2-thienylmethyl)indole-4-carbaldehyde as pale yellow crystals. The yield thereof was found to be 33%.

출처 및 근거

ORD 기록: ord-b94a6aca0ff0439087d60dd97479227e
출처 데이터셋: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05811439

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