Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → N-(2,2-dimethoxyethyl)-N-methanesulphonyl-4-fluoro-3-methoxyaniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | N-(2,2-dimethoxyethyl)-4-fluoro-3-methoxyaniline | HCID 22570019 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(2,2-dimethoxyethyl)-N-methanesulphonyl-4-fluoro-3-methoxyaniline | HCID 22570034 | 97.6% |
반응 단계
N-(2,2-dimethoxyethyl)-4-fluoro-3-methoxyaniline (1.46 g, 6.37 mmol) in dichloromethane (20 ml) was treated with pyridine (0.5 g 6.37 mmol) and methanesulphonyl chloride (766 mg, 6.69 mmol) and the mixture stirred until the reaction was complete by tlc. Aqueous work up and removal of solvent in vacuo gave N-(2,2-dimethoxyethyl)-N-methanesulphonyl-4-fluoro-3-methoxyaniline 1.91 g
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06855715B1 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-f7292c86d35d44d4acc5a0008826e6a7 |
| 출처 메모 | uspto-grants-2005_02 |