Pyridine → N-(2,2-dimethoxyethyl)-N-methanesulphonyl-4-fluoro-3-methoxyaniline

HRID 23948

반응식

HRID 23948 반응식
[CH3:1][O:2][CH:3]([O:15][CH3:16])[CH2:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([F:12])=[C:8]([O:13][CH3:14])[CH:7]=1.N1C=CC=CC=1.[CH3:23][S:24](Cl)(=[O:26])=[O:25]>ClCCl>[CH3:16][O:15][CH:3]([O:2][CH3:1])[CH2:4][N:5]([S:24]([CH3:23])(=[O:26])=[O:25])[C:6]1[CH:11]=[CH:10][C:9]([F:12])=[C:8]([O:13][CH3:14])[CH:7]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 31297Methanesulfonyl chlorideHCID 22570019N-(2,2-dimethoxyethyl)-4-fluoro-3-methoxyaniline

생성물 1

HCID 22570034N-(2,2-dimethoxyethyl)-N-methanesulphonyl-4-fluoro-3-methoxyaniline수율 97.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

N-(2,2-dimethoxyethyl)-4-fluoro-3-methoxyaniline (1.46 g, 6.37 mmol) in dichloromethane (20 ml) was treated with pyridine (0.5 g 6.37 mmol) and methanesulphonyl chloride (766 mg, 6.69 mmol) and the mixture stirred until the reaction was complete by tlc. Aqueous work up and removal of solvent in vacuo gave N-(2,2-dimethoxyethyl)-N-methanesulphonyl-4-fluoro-3-methoxyaniline 1.91 g

후처리

  1. customAqueous work up and removal of solvent in vacuo

출처 및 근거

ORD 기록
ord-f7292c86d35d44d4acc5a0008826e6a7
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855715B1

연결된 노트

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