Benzaldehyde → N-(alpha-phenylsulphonyl-benzyl)benzamide

HRID 2394804노트

반응식

HRID 2394804 반응식
[C:1]1([S:7]([O-:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na+].[C:11]([NH2:19])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[CH:20](=O)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.CO>O.C(O)=O>[C:1]1([S:7]([CH:20]([NH:19][C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

7

반응물 4

HCID 240BenzaldehydeHCID 887MethanolHCID 2331BenzamideHCID 2723840Benzenesulfinic acid, sodium salt

생성물 1

HCID 18974355N-(alpha-phenylsulphonyl-benzyl)benzamide수율 15.6%

시약·촉매·용매 2

HCID 284Formic Acid용매HCID 962Water용매

반응 조건

온도
20 °C

실험 절차

A solution of 40.2 g of sodium phenylsulphinate in 200 cm3 of water is introduced into a 500 cm3 reactor equipped with a magnetic stirrer and a reflux condenser. A mixture of 12.35 g of benzamide and 21.22 g of benzaldehyde is then added. 60 cm3 of methanol are then added so as to obtain an off-white emulsion and then 7.54 cm3 of formic acid (d=1.22) are added. After stirring for 41 hours 30 minutes at a temperature in the region of 20° C., the mixture is heated for 3 hours at 65° C. After filtration through sintered glass No. 4, the product obtained is washed with twice 15 cm3 of isopropyl ether and then with twice 15 cm3 of water. After drying, there are obtained, with a yield of 15.6%, 5.48 g of N-(α-phenylsulphonyl-benzyl)benzamide.

후처리

  1. customequipped with a magnetic stirrer and a reflux condenser
  2. additionis then added
  3. customto obtain an off-white emulsion
  4. temperaturethe mixture is heated for 3 hours at 65° C
  5. filtrationAfter filtration through sintered glass No
  6. custom4, the product obtained
  7. washis washed with twice 15 cm3 of isopropyl ether
  8. customAfter drying

출처 및 근거

ORD 기록
ord-fff0801a5bd2497aa76faa86410e4194
출처 데이터셋
uspto-grants-1998_09
특허 번호
US05811550

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