참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Tert-butyl 4-hydroxypiperidine-1-carboxylate | HCID 643502 | — |
| 반응물 | 2-Chloropyridine--hydrogen chloride (1/1) | HCID 15619920 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-Boc-4-(2-pyridyloxy)piperidine | HCID 21906039 | 72% |
반응 단계
1-t-Butoxycarbonyl-4-piperidinol (5.0 g 24.88 mmol) in dry dimethylformamide (60 ml) was treated with sodium hydride (60% 2.99 g 74.75 mmol) at room temperature under argon and then with 2-chloropyridine hydrochloride (4.1 g 27.33 mmol). Then mixture was heated at 80° C. overnight. After cooling the reaction was carefully quenched with water (5 ml) and then diluted with more water (20 ml) and extracted with ethyl acetate (30 ml). The organic solution was washed with sat. sodium bicarbonate, dried (MgSO4) and evaporated to give 1-t-butoxycarbonyl-4-(2-pyridoxy)piperidine (4.96 g 72%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06855715B1 |
|---|
| 출처 데이터셋 | uspto-grants-2005_02 |
|---|
| ORD ID | ord-390aae966993417181c270dae2276020 |
|---|
| 출처 메모 | uspto-grants-2005_02 |
|---|
