1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene → 1-[4-(2-Quinolylthio)phenyl]-3-(4-chloro-3-trifluoromethylphenyl)urea

HRID 2395348

반응식

HRID 2395348 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=2)=[CH:4][CH:3]=1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]=[C:27]=[O:28])=[CH:22][C:21]=1[C:29]([F:32])([F:31])[F:30]>>[N:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:17]=[CH:18][C:9]=1[S:8][C:5]1[CH:4]=[CH:3][C:2]([NH:1][C:27]([NH:26][C:23]2[CH:24]=[CH:25][C:20]([Cl:19])=[C:21]([C:29]([F:31])([F:30])[F:32])[CH:22]=2)=[O:28])=[CH:7][CH:6]=1

참가 물질

3

반응물 2

HCID 27332651-Chloro-4-isocyanato-2-(trifluoromethyl) benzeneHCID 226371302-(4-Aminophenylthio)quinoline

생성물 1

HCID 189716631-[4-(2-Quinolylthio)phenyl]-3-(4-chloro-3-trifluoromethylphenyl)urea

실험 절차

2-(4-Aminophenylthio)quinoline (3.9 mmoles, 1.0 g) and 4-chloro-3-trifluoromethylphenylisocyanate (3.9 mmoles, 0.85 g) were reacted according to procedure A to yield the title compound, 0.8 g, 43%. Mass Spec (FD) 463. Calculated for C23H15ClF3N3OS: C, 58.29; H, 3.19; N, 8.87. Found: C, 58.56; H, 3.43; N. 9.02. M Pt 194°-195° C.

출처 및 근거

ORD 기록
ord-ba28262cdc5b497d88e56f7fd870ca56
출처 데이터셋
uspto-grants-1998_09
특허 번호
US05814646

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