Methanol → Dimethyl 2,4-dichloroisophthaloate

HRID 2395556노트

반응식

HRID 2395556 반응식
[Cl:1][C:2]1[C:10]([C:11]([O:13][CH3:14])=[O:12])=[C:9]([Cl:15])[CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH3:16][OH:17]>>[Cl:1][C:2]1[C:10]([C:11]([O:13][CH3:14])=[O:12])=[C:9]([Cl:15])[CH:8]=[CH:7][C:3]=1[C:4]([O:17][CH3:16])=[O:5]

참가 물질

3

반응물 2

HCID 887MethanolHCID 189891562,4-Dichloro-3-methoxycarbonylbenzoylchloride

생성물 1

HCID 18989135Dimethyl 2,4-dichloroisophthaloate

실험 절차

2,4-Dichloro-3-methoxycarbonylbenzoylchloride (34.76 g) was stirred and heated under reflux with methanol for 15 hours. After cooling, the solvent was evaporated and the residue recrystallised from cyclohexane to give dimethyl 2,4-dichloroisophthaloate (16.04 g) as a beige solid, NMR (DMSO D6) δ3.87 (3H,s), 3.94 (3H,s), 7.74 (1H,d), 7.94 (1H,d).

후처리

  1. temperatureheated
  2. temperatureAfter cooling
  3. customthe solvent was evaporated
  4. customthe residue recrystallised from cyclohexane

출처 및 근거

ORD 기록
ord-50de8a8e5889458aa897d22b26e783fe
출처 데이터셋
uspto-grants-1996_02
특허 번호
US05489570

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