Thionyl Chloride → 2,4-Dichloro-3-methoxycarbonylbenzoylchloride

HRID 2395557노트

반응식

HRID 2395557 반응식
[Cl:1][C:2]1[C:10]([C:11]([O:13][CH3:14])=[O:12])=[C:9]([Cl:15])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:18])=O>>[Cl:1][C:2]1[C:10]([C:11]([O:13][CH3:14])=[O:12])=[C:9]([Cl:15])[CH:8]=[CH:7][C:3]=1[C:4]([Cl:18])=[O:5]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 151328742,4-Dichloro-3-(methoxycarbonyl)benzoic acid

생성물 1

HCID 189891562,4-Dichloro-3-methoxycarbonylbenzoylchloride

실험 절차

2,4-Dichloro-3-methoxycarbonylbenzoic acid (32.37 g) and thionyl chloride (100 ml) was heated under reflux with stirring for 3 hours. The mixture was cooled and evaporated in vacuo, then re-evaporated after addition of toluene to give 2,4-dichloro-3-methoxycarbonylbenzoyl chloride (34.76 g) as a dark brown oil. This was used in the next stage without purification.

후처리

  1. temperatureunder reflux
  2. temperatureThe mixture was cooled
  3. customevaporated in vacuo
  4. customre-evaporated
  5. additionafter addition of toluene

출처 및 근거

ORD 기록
ord-e80269615aba4a99b68b98501f9df53a
출처 데이터셋
uspto-grants-1996_02
특허 번호
US05489570

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