Acetic Acid → 4-(2,4-Difluorophenyl)-1,1,1-trifluoro-4-hydroxy-3-buten-2-one

HRID 2395633

반응식

HRID 2395633 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].[F:12][C:13]([F:20])([F:19])[C:14](OCC)=[O:15].C[O-].[Na+].CO.C(O)(=O)C>C(OCC)C>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:11])=[CH:10][C:14](=[O:15])[C:13]([F:20])([F:19])[F:12]

참가 물질

7

반응물 5

HCID 176Acetic AcidHCID 887MethanolHCID 9794Ethyl trifluoroacetateHCID 677702,4-DifluoroacetophenoneHCID 10942334Sodium Methoxide

생성물 1

HCID 699347784-(2,4-Difluorophenyl)-1,1,1-trifluoro-4-hydroxy-3-buten-2-one수율 97.4%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
25 °C

실험 절차

To a solution of 40.0 g (0.256 moles) 2',4'-difluoroacetophenone (commercially available) in 400 mL diethyl ether at 0° C. was added 40 mL (0.405 moles) ethyl trifluoroacetate. At 5° C., 80 mL of a 25% wt. sodium methoxide in methanol (0.37 moles) were added over 15 minutes. The reaction mixture was stirred overnight at 25° C. The mixture was poured over 300 mL ice water and 21.3 mL (0.37 moles) acetic acid were added. The organic layer was washed two times with water, dried over anhydrous MgSO4, and concentrated in vacuo to give 62.85 g (97%) 4-(2,4-difluorophenyl)-1,1,1-trifluoro-4-hydroxy-3-buten-2-one as a yellow oil; 1HNMR (CDCl3) ppm: 6.61 (s,1H), 6.87 (m,1H), 6.97 (m,1H), 7.97 (m,1H).

후처리

  1. additionwere added
  2. washThe organic layer was washed two times with water
  3. dry with materialdried over anhydrous MgSO4
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-279163a71ded49b889bb31539090eac4
출처 데이터셋
uspto-grants-1996_02
특허 번호
US05489571

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