Acetic Acid → 4-[(3,4-Dihydroxy-5-cyanophenyl)methylene]-3,5-pentanedione

HRID 2395722

반응식

HRID 2395722 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([C:11]#[N:12])[C:9]=1[OH:10])[CH:5]=O.[CH3:13][CH2:14][C:15](=[O:19])[CH2:16][CH:17]=[O:18].N1CCCCC1.C(O)(=O)C>C1(C)C=CC=CC=1>[OH:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:16]([CH:17]=[O:18])[C:15](=[O:19])[CH2:14][CH3:13])[CH:7]=[C:8]([C:11]#[N:12])[C:9]=1[OH:10]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 8082PiperidineHCID 12179Pentanal, 3-oxo-HCID 152925835-Formyl-2,3-dihydroxybenzonitrile

생성물 1

HCID 540982264-[(3,4-Dihydroxy-5-cyanophenyl)methylene]-3,5-pentanedione

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture 1.6 g of 3,4-dihydroxy-5-cyanobenzaldehyde, 2.0 g of 3,5-pentanedione, 0.2 ml of piperidine and 0.6 ml of acetic acid in 70 ml of toluene was refluxed for 2 h with Dean-Stark separator. The solvent was evaporated in vacuo and the residue was crystallized from acetone-cyclohexane. mp 228°-232° C.

후처리

  1. customThe solvent was evaporated in vacuo
  2. customthe residue was crystallized from acetone-cyclohexane

출처 및 근거

ORD 기록
ord-dd5989d39665475cb846a8388674bb9e
출처 데이터셋
uspto-grants-1996_02
특허 번호
US05489614

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