Potassium Hydroxide → 5-bromo-6-methoxy-1H-indole-2-carboxylic acid

HRID 2395769노트

반응식

HRID 2395769 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[O:11][CH3:12])[NH:7][C:6]([C:13]([O:15]C)=[O:14])=[CH:5]2.[OH-].[K+]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[O:11][CH3:12])[NH:7][C:6]([C:13]([OH:15])=[O:14])=[CH:5]2

참가 물질

3

반응물 2

HCID 14797Potassium HydroxideHCID 16726758methyl 5-bromo-6-methoxy-1H-indole-2-carboxylate

생성물 1

HCID 194188695-bromo-6-methoxy-1H-indole-2-carboxylic acid

실험 절차

Following the general procedure of PREPARATION 63 and making non-critical variations but starting with methyl 5-bromo-6-methoxyindole carboxylate (PREPARATION 81, 3.31 g) and potassium hydroxide (0.98 g), the title compound is obtained, NMR (300 MHz, CD3OD) 7.79, 7.03, 7.01 and 3.89 δ.

후처리

  1. customthe general procedure of PREPARATION 63

출처 및 근거

ORD 기록
ord-a5e183ffc1aa497a846807de9d038e6d
출처 데이터셋
uspto-grants-1996_02
특허 번호
US05489593

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