Potassium Hydroxide → 6-(dimethylamino)-1H-indole-2-carboxylic acid

HRID 2395773노트

반응식

HRID 2395773 반응식
[CH3:1][N:2]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[C:9]([C:13]([O:15]C)=[O:14])[NH:10]2)=[CH:6][CH:5]=1)[CH3:3].[OH-].[K+]>>[CH3:3][N:2]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[C:9]([C:13]([OH:15])=[O:14])[NH:10]2)=[CH:6][CH:5]=1)[CH3:1]

참가 물질

3

반응물 2

HCID 14797Potassium HydroxideHCID 4715276methyl 6-(dimethylamino)-1H-indole-2-carboxylate

생성물 1

HCID 51599086-(dimethylamino)-1H-indole-2-carboxylic acid

실험 절차

Following the general procedure of PREPARATION 63 and making non-critical variations but starting with methyl 6-(N,N-dimethylamino)indole-2-carboxylate (PREPARATION 88, 0.80 g), potassium hydroxide (0.25 g), the title compound is obtained, NMR (300 MHz, CD3OD) 7.62, 7.13, 7.11, 7.01, and 3.11 δ.

후처리

  1. customthe general procedure of PREPARATION 63

출처 및 근거

ORD 기록
ord-2a2183cb021549fb8816cb1dc407b928
출처 데이터셋
uspto-grants-1996_02
특허 번호
US05489593

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