Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Citric Acid → Sufentanil Citrate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Citric Acid | HCID 311 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Sufentanil | HCID 41693 | — |
| 반응물 | 164790-60-7 | HCID 18463211 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Sufentanil Citrate | HCID 65494 | — |
반응 단계
Sufentanil HCl obtained in Example 8 was suspended in hot water and adjusted to pH 10-11 with 10% aqueous potassium hydroxide and extracted with ether. The organic layer washed with water, dried and evaporated to give the free base with an LC purity profile of 99.62%. An equivalent of sufentanil free base with anhydrous citric acid was warmed in 100% ethanol. After removal of ethanol the fluffy white powder was dried in the vacuum oven at 56° C. for 48 hrs. Sufentanil citrate thus obtained passed all USP tests.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05489689 |
| 출처 데이터셋 | uspto-grants-1996_02 |
| ORD ID | ord-c4d7fd8d38be478e8f997c76ebc4fde9 |
| 출처 메모 | uspto-grants-1996_02 |