Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 1-Boc-4-[2-(4-pyridinyl)ethyl]piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | 4-Vinylpyridine | HCID 7502 | — |
| 반응물 | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 1-Boc-4-[2-(4-pyridinyl)ethyl]piperazine | HCID 22321631 | 46.3% |
반응 단계
1-Boc-piperazine (4.0 g, 21.5 mmol), 4-vinylpyridine (2.94 g, 27.9 mmol), and acetic acid (1.29 g, 21.5 mmol) were mixed in ethanol and heated to reflux for 48 h. The mixture was cooled to room temperature and concentrated under vacuum to provide 1-Boc-4-[2-(4-pyridinyl)ethyl]-piperazine (2.9 g, 45%) as an off white solid. The product was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06855715B1 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-0cbde3c2a82a4113837f2babf03f86ec |
| 출처 메모 | uspto-grants-2005_02 |