3-Aminoquinuclidine → (S)-N-(1-azabicyclo[2.2.2]oct-3-yl)-2-butylbenzamide

HRID 2396007노트

반응식

HRID 2396007 반응식
[CH2:1]([C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7]([OH:9])=O)[CH2:2][CH2:3][CH3:4].[NH2:14][CH:15]1[CH:20]2[CH2:21][CH2:22][N:17]([CH2:18][CH2:19]2)[CH2:16]1.N[C@H]1C2CCN(CC2)C1>>[N:17]12[CH2:22][CH2:21][CH:20]([CH2:19][CH2:18]1)[C@H:15]([NH:14][C:7](=[O:9])[C:6]1[CH:10]=[CH:11][CH:12]=[CH:13][C:5]=1[CH2:1][CH2:2][CH2:3][CH3:4])[CH2:16]2

참가 물질

4

반응물 3

HCID 1232383-AminoquinuclidineHCID 171526Benzoic acid, butyl-HCID 719216(S)-quinuclidin-3-amine

생성물 1

HCID 54099080(S)-N-(1-azabicyclo[2.2.2]oct-3-yl)-2-butylbenzamide

실험 절차

Proceeding as in Example 1, Method A, but replacing 2,3-dimethyl benzoic acid with 2-butylbenzoic acid and (RS)-3-amino-1-azabicyclo[2.2.2]octane with (S)-3-amino-1-azabicyclo[2.2.2]octane gave (S)-N-(1-azabicyclo[2.2.2]oct-3-yl)-2-butylbenzamide.

출처 및 근거

ORD 기록
ord-aa257d01133348828124819206e9550a
출처 데이터셋
uspto-grants-1996_02
특허 번호
US05491148

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