Ethyl 2-pyridylacetate → Nsc74475

HRID 23961

반응식

HRID 23961 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9].[N:13]([O-])=[O:14].[Na+]>C(O)(=O)C.O>[OH:14][N:13]=[C:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)[C:8]([O:10][CH2:11][CH3:12])=[O:9]

참가 물질

5

반응물 2

HCID 75960Ethyl 2-pyridylacetateHCID 23668193Sodium Nitrite

생성물 1

HCID 135543845Nsc74475수율 95.2%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매2회

실험 절차

To a stirring solution of ethyl pyridine-2-acetate (12.6 g, 76.3 mmol) in acetic acid (19 mL) at 5° C. was added a solution of sodium nitrite (6.05 g, 87.7 mmol) in water (12 mL) at a rate sufficient to maintain the internal temperature below 15° C. After complete addition and an additional 30 min, an additional 30 mL of water was added. The resulting white precipitate was filtered, washed with water, saturated aqueous NaHCO3, and again with water. The solid was then dried under vacuum to give 14.1 g (95%) of the title compound.

후처리

  1. temperatureto maintain the internal temperature below 15° C
  2. additionAfter complete addition
  3. filtrationThe resulting white precipitate was filtered
  4. washwashed with water, saturated aqueous NaHCO3
  5. customThe solid was then dried under vacuum

출처 및 근거

ORD 기록
ord-a7f6fb272a334a2483dacd0a71bbf705
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855715B1

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