(2S,3S)-2-t-butoxycarbonylamino-1-cyclohexyl-3-hydroxy-5-methylhexane → (2S,3S)-2-amino-1-cyclohexyl-3-hydroxy-5-methylhexane

HRID 2396145노트

반응식

HRID 2396145 반응식
C(OC([NH:8][C@H:9]([C@@H:17]([OH:22])[CH2:18][CH:19]([CH3:21])[CH3:20])[CH2:10][CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)=O)(C)(C)C>FC(F)(F)C(O)=O>[NH2:8][C@H:9]([C@@H:17]([OH:22])[CH2:18][CH:19]([CH3:20])[CH3:21])[CH2:10][CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1

참가 물질

3

반응물 1

HCID 57261833(2S,3S)-2-t-butoxycarbonylamino-1-cyclohexyl-3-hydroxy-5-methylhexane

생성물 1

HCID 22861533(2S,3S)-2-amino-1-cyclohexyl-3-hydroxy-5-methylhexane수율 100.4%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

A solution of (2S,3S)-2-t-butoxycarbonylamino-1-cyclohexyl-3-hydroxy-5-methylhexane (120 mg) in trifluoroacetic acid (3 ml) was stirred at 0° C. for 30 minutes. After evaporation of the solvent, the residue was dissolved in ethyl acetate (10 ml). The solution was washed with saturated sodium bicarbonate solution and saturated sodium chloride solution, dried over magnesium sulfate, and evaporated in vacuo to give (2S,3S)-2-amino-1-cyclohexyl-3-hydroxy-5-methylhexane (82 mg) as an oil. Rf: 0.30 (chloroform: methanol: acetic acid, 16:1:1, V/V)

후처리

  1. customAfter evaporation of the solvent
  2. dissolutionthe residue was dissolved in ethyl acetate (10 ml)
  3. washThe solution was washed with saturated sodium bicarbonate solution and saturated sodium chloride solution
  4. dry with materialdried over magnesium sulfate
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-510f04a479724d008b74098e86518c92
출처 데이터셋
uspto-grants-1996_02
특허 번호
US05491132

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