Potassium Hydroxide → Imidazo(1,2-a)pyrimidine-2-carboxylic acid

HRID 23962노트

반응식

HRID 23962 반응식
[N:1]1[C:2]([C:10]([O-:12])=[O:11])=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[N:6][C:5]=12.[OH-].[K+]>C(O)C>[N:1]1[C:2]([C:10]([OH:12])=[O:11])=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[N:6][C:5]=12

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 6987274Imidazo[1,2-a]pyrimidine-2-carboxylate

생성물 1

HCID 326100Imidazo(1,2-a)pyrimidine-2-carboxylic acid수율 83%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a stirring solution of ethyl 1-(imidazo[1,2-a]pyrimidine-2-carboxylate (1 g, 5.2 mmol) [Abignente, et al. Eur. J. Med. Chem. (1994) 29, 279] in ethanol (30 mL) was added 2 N aqueous KOH (10 mL, 20 mmol). The solution was heated to reflux; and after 2 h, the heating mantle was removed, the solution was allowed to cool and the solvent was removed by rotary evaporation. The residue was dissolved in water (20 mL) and acidified to pH 3 with 5 N HCl. The resulting precipitate was filtered, washed with water and dried in vacuo to give 700 mg (83%) of a tan solid.

후처리

  1. temperatureThe solution was heated to reflux
  2. customthe heating mantle was removed
  3. temperatureto cool
  4. customthe solvent was removed by rotary evaporation
  5. dissolutionThe residue was dissolved in water (20 mL)
  6. filtrationThe resulting precipitate was filtered
  7. washwashed with water
  8. customdried in vacuo

출처 및 근거

ORD 기록
ord-81b55db0f6af485f8483d472d1550f6b
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855715B1

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