3-Bromo-1-propanol → 3-[(4,6-Diphenyl-2-pyridyl)oxy]-1-propanol

HRID 2396508

반응식

HRID 2396508 반응식
[C:1]1([C:7]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[NH:10][C:9](=[O:19])[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:21][CH2:22][CH2:23][OH:24]>C(=O)([O-])[O-].[Ag+2].C1(C)C=CC=CC=1>[C:1]1([C:7]2[CH:12]=[C:11]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:10]=[C:9]([O:19][CH2:21][CH2:22][CH2:23][OH:24])[CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 2

HCID 123083-Bromo-1-propanolHCID 38462014,6-Diphenyl-2-pyridone

생성물 1

HCID 189872833-[(4,6-Diphenyl-2-pyridyl)oxy]-1-propanol

시약·촉매·용매 2

HCID 178418647HCID 178418647, 화합물촉매HCID 1140Toluene용매

실험 절차

The procedure in Example 4 is followed but using 4,6-diphenyl-2-pyridone (15 g), freshly distilled 3-bromo-1-propanol (16.5 cc), silver carbonate (8.4 g) and toluene (600 cc). The reaction mixture is refluxed for 144 hours. The product is purified by chromatography under pressure on silica gel (30-60 mm; eluent: n-hexane-ethyl acetate 7-3). (white solid; m.p.=94° C.)

후처리

  1. temperatureThe reaction mixture is refluxed for 144 hours
  2. customThe product is purified by chromatography under pressure on silica gel (30-60 mm; eluent: n-hexane-ethyl acetate 7-3)

출처 및 근거

ORD 기록
ord-3ba0fce85e394da99a4bd7067d820af7
출처 데이터셋
uspto-grants-1996_02
특허 번호
US05492915

연결된 노트

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