Hydrogen Peroxide → Pyridine, 3-(phenylmethyl)-, 1-oxide

HRID 2396758노트

반응식

HRID 2396758 반응식
[CH2:1]([C:8]1[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:14]O>C(O)(=O)C>[CH2:1]([C:8]1[CH:9]=[N+:10]([O-:14])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 784Hydrogen Peroxide2회HCID 121123-Benzylpyridine

생성물 1

HCID 54142008Pyridine, 3-(phenylmethyl)-, 1-oxide수율 100%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 3-benzylpyridine (25 g, 0.148 tool) in hydrogen peroxide (30%, 15.1 mL) and acetic acid (100 mL) was refluxed for one day. Then more hydrogen peroxide (3 mL) was added and the resulting mixture was refluxed overnight. The reaction mixture was then evaporated and partitioned between a mixture of 3 N HCl, brine and dichloromethane. The organic layer was separated, dried and evaporated to give the desired compound (27.6 g, 100%).

후처리

  1. temperaturethe resulting mixture was refluxed overnight
  2. customThe reaction mixture was then evaporated
  3. custompartitioned between a mixture of 3 N HCl, brine and dichloromethane
  4. customThe organic layer was separated
  5. customdried
  6. customevaporated

출처 및 근거

ORD 기록
ord-3e12e8445c50462ea540c0fda3bb7416
출처 데이터셋
uspto-grants-1996_02
특허 번호
US05494919

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