Benzenesulfonyl fluoride, p-chloro- → (2S,4S)-1-Tert-butyl 2-methyl 4-fluoropyrrolidine-1,2-dicarboxylate

HRID 2397138노트

반응식

HRID 2397138 반응식
COC(=O)[C@@H]1C[C@H](O)CN1C(=O)OC(C)(C)C.O=S(=O)(F)c1ccc(Cl)cc1>C1CCC2=NCCCN2CC1.C1CCOC1>COC(=O)[C@@H]1C[C@H](F)CN1C(=O)OC(C)(C)C

참가 물질

5

반응물 2

HCID 94992Benzenesulfonyl fluoride, p-chloro-HCID 10752873N-Boc-cis-4-hydroxy-L-proline methyl ester

생성물 1

HCID 10977773(2S,4S)-1-Tert-butyl 2-methyl 4-fluoropyrrolidine-1,2-dicarboxylate수율 25%

시약·촉매·용매 2

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene시약HCID 8028Tetrahydrofuran용매2회

후처리

  1. addition기록된 절차가 없습니다

출처 및 근거

ORD 기록
ord-4389dac19b99452180cd2c0b5baac96b
출처 데이터셋
Deoxyfluorination screen
원본 링크
출처 보기

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