Benzene → Isobutyl 3,7,11-trimethyldodeca-2,4-dienoate

HRID 2397300노트

반응식

HRID 2397300 반응식
[CH3:1][C:2]([CH:7]=[CH:8][CH2:9][CH:10]([CH3:17])[CH2:11][CH2:12][CH2:13][CH:14]([CH3:16])[CH3:15])=[CH:3][C:4]([OH:6])=[O:5].[C:18](Cl)(=O)C(Cl)=O.[CH:24]1[CH:29]=[CH:28]C=CC=1>>[CH3:1][C:2]([CH:7]=[CH:8][CH2:9][CH:10]([CH3:17])[CH2:11][CH2:12][CH2:13][CH:14]([CH3:16])[CH3:15])=[CH:3][C:4]([O:6][CH2:18][CH:29]([CH3:28])[CH3:24])=[O:5]

참가 물질

4

반응물 3

HCID 241BenzeneHCID 65578Oxalyl chlorideHCID 1037233,7,11-Trimethyldodeca-2,4-dienoic acid

생성물 1

HCID 53880681Isobutyl 3,7,11-trimethyldodeca-2,4-dienoate

실험 절차

To a solution of 4.15 g. of 3,7,11-trimethyldodeca-2,4-dienoic acid in 100 ml. of dry benzene, under nitrogen, is added 5.1 ml. of oxalyl chloride. After 2 hours, solvent is removed under reduced pressure and 100 ml. of fresh dry benzene and 6.4 ml. of dry isobutyl alcohol is added. The reaction mixture is concentrated and the concentrate is stirred over 20 g. of activated alumina in pentane for 0.5 hr. and filtered. The filtrate is washed, dried and evaporated under reduced pressure to give isobutyl 3,7,11-trimethyldodeca-2,4-dienoate which can be purified by distillation.

후처리

  1. customsolvent is removed under reduced pressure and 100 ml
  2. additionof dry isobutyl alcohol is added
  3. concentrationThe reaction mixture is concentrated
  4. waitof activated alumina in pentane for 0.5 hr
  5. filtrationand filtered
  6. washThe filtrate is washed
  7. customdried
  8. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-7da2645935904472b95f553be7d893d1
출처 데이터셋
uspto-grants-1977_05
특허 번호
US04021461

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