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p-Toluenesulfonic acid → (4-amino-2-methyl-5-phenyl-1H-pyrrol-3-yl)-phenylmethanone

HRID 2397529
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인쇄 미리보기

반응식

HRID 2397529 반응식
[NH2:1][CH:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[C:3]#[N:4].[C:11]([CH2:19][C:20](=O)[CH3:21])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1.[O-]CC.[Na+]>C(O)C.C1C=CC=CC=1>[NH2:4][C:3]1[C:19]([C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:20]([CH3:21])[NH:1][C:2]=1[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 6101p-Toluenesulfonic acidHCID 7166BenzoylacetoneHCID 408382-Amino-2-phenylacetonitrileHCID 2723922Sodium ethoxide

생성물 1

HCID 3042143(4-amino-2-methyl-5-phenyl-1H-pyrrol-3-yl)-phenylmethanone

시약·촉매·용매 2

HCID 241Benzene용매
HCID 702
Ethanol
용매

실험 절차

2-Amino-2-phenyl-acetonitrile (0.04 mole) and benzoyl acetone (0.04 mole) are refluxed for four hours in 30 ml. of anhydrous benzene in the presence of 100 mg. of p-toluenesulfonic acid. After cooling the reaction mixture is filtered and the solvent is evaporated off to give an oily residue which is dissolved in an ethanol solution containing sodium ethoxide (0.041 mole) and the mixture is allowed to stand for 12 hours at the room temperature. The solid precipitate which forms is recovered by filtration.

후처리

  1. temperatureAfter cooling the reaction mixture
  2. filtrationis filtered
  3. customthe solvent is evaporated off
  4. customto give an oily residue which
  5. filtrationThe solid precipitate which forms is recovered by filtration

출처 및 근거

ORD 기록
ord-708deb1f080b494f8f9119208f0d1642
출처 데이터셋
uspto-grants-1977_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04022766

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