Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl bromoacetate → 6-chloro-2-ethyl-1-ethoxycarbonylmethyl-1H-imidazo[4,5-b]quinoxaline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl bromoacetate | HCID 7748 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 6-chloro-2-ethyl-1H-imidazo[4,5-b]quinoxaline | HCID 178437541 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 6-chloro-2-ethyl-1-ethoxycarbonylmethyl-1H-imidazo[4,5-b]quinoxaline | HCID 21435966 | — |
반응 단계
A mixture of 100 parts of 6-chloro-2-ethyl-1H-imidazo[4,5-b]quinoxaline, 70 parts of anhydrous potassium carbonate, 75 parts of ethyl bromoacetate, and 600 parts of anhydrous dimethylformamide was heated at 100° for 2.5 hours. The mixture was filtered and the crude product was precipitated from the filtrate by addition of 1200 parts of water, collected by filtration, washed with water, ethanol, and ether, and airdried. Recrystallization from 95% ethanol afforded 63 parts of 6-chloro-2-ethyl-1-ethoxycarbonylmethyl-1H-imidazo[4,5-b]quinoxaline, m.p. 174°-175°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04022777 |
| 출처 데이터셋 | uspto-grants-1977_05 |
| ORD ID | ord-2d02fb0618364871867ce677d5505903 |
| 출처 메모 | uspto-grants-1977_05 |