Dimethylformamide → 6-chloro-2-ethyl-1-(1-formamido-2,2,2-trichloroethyl)-1H-imidazo[4,5-b]quinoxaline

HRID 2397549

반응식

HRID 2397549 반응식
CN(C)C=O.[Cl:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]1[NH:17][C:18]([CH2:20][CH3:21])=[N:19][C:11]1=[N:10]2.C(N(CC)CC)C.[CH:29]([NH:31][CH:32](Cl)[C:33]([Cl:36])([Cl:35])[Cl:34])=[O:30]>O>[Cl:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]1[N:17]([CH:32]([NH:31][CH:29]=[O:30])[C:33]([Cl:36])([Cl:35])[Cl:34])[C:18]([CH2:20][CH3:21])=[N:19][C:11]1=[N:10]2

참가 물질

6

반응물 4

HCID 6228Dimethylformamide2회HCID 8471TriethylamineHCID 19312N-(1,2,2,2-Tetrachloroethyl)formamideHCID 1784375416-chloro-2-ethyl-1H-imidazo[4,5-b]quinoxaline

생성물 1

HCID 214360106-chloro-2-ethyl-1-(1-formamido-2,2,2-trichloroethyl)-1H-imidazo[4,5-b]quinoxaline

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 240 ml of dry dimethylformamide warmed to 50° was added 3.5 parts of 6-chloro-2-ethyl-1H-imidazo[4,5-b]quinoxaline and 1.75 parts of triethylamine. The resulting solution was added, with stirring, to a 500 ml round-bottomed flask containing 3.3 parts of 1-formamido-1,2,2,2-tetrachloroethane and 45 parts of dry dimethylformamide at room temperature. After standing for 75 minutes, the clear solution was poured onto a mixture of 1500 parts of ice and water. The resulting solids were collected, washed with water and dried to give 4.6 parts of 6-chloro-2-ethyl-1-(1-formamido-2,2,2-trichloroethyl)-1H-imidazo[ 4,5-b]quinoxaline, decomposing at 109°.

후처리

  1. additionThe resulting solution was added
  2. customThe resulting solids were collected
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-b6a84695dae94eddb785bdd0ec374139
출처 데이터셋
uspto-grants-1977_05
특허 번호
US04022777

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