p-Toluenesulfonic acid monohydrate → p-Toluenesulfonic acid

HRID 2397624노트

반응식

HRID 2397624 반응식
[OH:1][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH2:3][C:4]#[N:5].NCC[C@@H:14]([OH:20])[CH2:15][CH2:16][CH2:17][CH2:18]C.O.[C:22]1([CH3:32])[CH:27]=[CH:26][C:25]([S:28]([OH:31])(=[O:30])=[O:29])=[CH:24][CH:23]=1>>[C:22]1([CH3:32])[CH:23]=[CH:24][C:25]([S:28]([OH:31])(=[O:29])=[O:30])=[CH:26][CH:27]=1.[NH2:5][CH2:4][CH2:3][C@@H:2]([O:1][CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18][O:20]1)[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

참가 물질

5

반응물 3

HCID 521998p-Toluenesulfonic acid monohydrateHCID 134138033-HydroxycaprylonitrileHCID 227975051-amino-3(S)-octanol

생성물 2

HCID 6101p-Toluenesulfonic acidHCID 540303281-Amino-3(S)-(tetrahydro-2H-pyran-2-yloxy)octane

실험 절차

This compound is prepared essentially by the same method as described in Example 1, Step A-2, except that the 3-hydroxycaprylonitrile is replaced by 1-amino-3(S)-octanol and slightly more than one equivalent of p-toluenesulfonic acid. hydrate is used. This method provides the p-toluenesulfonic acid salt of the title compound which is converted to the oily title compound by distribution between dilute sodium hydroxide and ether. The organic phase is washed with saturated aqueous brine, dried over sodium sulfate, and filtered. Evaporation of the filtrate in vacuo leaves the title compound as a residual oil.

후처리

  1. customThis compound is prepared essentially by the same method

출처 및 근거

ORD 기록
ord-15fdaa5ece704e8285f39984a93db8c1
출처 데이터셋
uspto-grants-1977_05
특허 번호
US04022794

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