Bromine → 2-Amino-5-bromo-4-fluoropyridin-3-ol

HRID 2397839노트

반응식

[NH2:1][C:2]1[C:7]([OH:8])=[C:6]([F:9])[CH:5]=[CH:4][N:3]=1.[Br:10]Br>>[NH2:1][C:2]1[C:7]([OH:8])=[C:6]([F:9])[C:5]([Br:10])=[CH:4][N:3]=1

참가 물질

반응물 2

HCID 24408Bromine

HCID 214366942-Amino-4-fluoropyridin-3-ol

생성물 1

HCID 214366732-Amino-5-bromo-4-fluoropyridin-3-ol

실험 절차

The 2-amino-4-fluoro-3-pyridinol from Example 2 and bromine in a molar ratio of 1:1 are heated in the vapor phase at 300° according to the procedure of McElvain and Goese [J. Am. Chem. Soc., 65, 2227 (1943)] to give 2-amino-5-bromo-4-fluoro-3-pyridinol. The latter with an equivalent amount of cesium fluoride by the procedure of Example 2gives 2-amino-4,5-difluoro-3-pyridinol.

출처 및 근거

ORD 기록: ord-0d6e8bd6608e46d4b8c876e7a650635a
출처 데이터셋: uspto-grants-1977_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04022897

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