HCID 21436737, 화합물 → HCID 21436740, 화합물

HRID 2397925노트

반응식

HRID 2397925 반응식
[Br-:1].[N+:2]([C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH:7]=[CH:8][N+:9]([CH2:15][CH2:16][CH3:17])=[CH:10]2)([O-])=O>CO.[Pt]=O>[BrH:1].[NH2:2][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH2:7][CH2:8][N:9]([CH2:15][CH2:16][CH3:17])[CH2:10]2

참가 물질

4

반응물 1

HCID 21436737HCID 21436737, 화합물

생성물 1

HCID 21436740HCID 21436740, 화합물수율 100.2%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 887Methanol용매

실험 절차

5-Nitro-2-n-propylisoquinolinium bromide (8.2 g) was dissolved in methanol (150 ml) and the solution hydrogenated over platinum oxide (0.6 g) at 45 psi. When the hydrogenation was complete, the catalyst was removed by filtration and the solvent removed in vacuo to leave a light orange solid residue of 5-amino-2-n-propyl-1,2,3,4-tetrahydroisoquinoline hydrobromide (7.5 g). This residue was recrystallized from ethanol and the product obtained as pale orange crystals, m.p. 238°-239.5° C.

후처리

  1. customthe catalyst was removed by filtration
  2. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-cceff6d68eeb4094a9558e8d4d59a204
출처 데이터셋
uspto-grants-1977_05
특허 번호
US04022900

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