Sodium Bicarbonate → 1alpha-Methyl-4-androstene-17beta,19-diol 17-propionate

HRID 2397973노트

반응식

HRID 2397973 반응식
[C:1]([O:5][C@H:6]1[CH2:11][CH2:10][C@H:9]2[C@H:12]3[C@H:27]([CH2:28][CH2:29][C@:7]12[CH3:8])[C@:20]1([CH2:21][O:22]C(=O)CC)[C:15](=[CH:16][CH2:17][CH2:18][C@@H:19]1[CH3:30])[CH2:14][CH2:13]3)(=[O:4])[CH2:2][CH3:3].C(=O)(O)[O-].[Na+]>CO>[C:1]([O:5][C@H:6]1[CH2:11][CH2:10][C@H:9]2[C@H:12]3[C@H:27]([CH2:28][CH2:29][C@:7]12[CH3:8])[C@:20]1([CH2:21][OH:22])[C:15](=[CH:16][CH2:17][CH2:18][C@@H:19]1[CH3:30])[CH2:14][CH2:13]3)(=[O:4])[CH2:2][CH3:3]

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 705838891alpha-Methyl-4-androstene-17beta,19-diol dipropionate

생성물 1

HCID 705847651alpha-Methyl-4-androstene-17beta,19-diol 17-propionate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1α-Methyl-4-androstene-17β,19-diol dipropionate is dissolved in a 10% aqueous methanol solution and one equivalent of sodium bicarbonate is added. The solution is stirred and heated at its reflux temperature for one hour and poured onto ice water with vigorous stirring. The precipitate is removed by filtration, air dried and crystallized from hexane to yield 1α-methyl-4-androstene-17β,19-diol 17-propionate.

후처리

  1. additionis added
  2. temperatureheated at its
  3. temperaturereflux temperature for one hour
  4. additionpoured onto ice water with vigorous stirring
  5. customThe precipitate is removed by filtration, air
  6. customdried
  7. customcrystallized from hexane

출처 및 근거

ORD 기록
ord-058026ca909142dd97a15bf7314057cc
출처 데이터셋
uspto-grants-1977_05
특허 번호
US04022769

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