Thionyl Chloride → 1-(2-Chloroethyl)-4-benzamidopiperidine

HRID 2398072노트

반응식

HRID 2398072 반응식
O[CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([NH:10][C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:6][CH2:5]1.S(Cl)([Cl:21])=O>C1C=CC=CC=1>[Cl:21][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([NH:10][C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:6][CH2:5]1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 203151761-(2-Hydroxyethyl)-4-benzamidopiperidine

생성물 1

HCID 213952311-(2-Chloroethyl)-4-benzamidopiperidine

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

1 Gram of 1-(2-hydroxyethyl)-4-benzamidopiperidine suspended in 2 milliliters of dry benzene was treated with 0.62 gram of thionyl chloride. The stirred mixture was refluxed for 3 hrs., then cooled and filtered to give the title compound as a light grey solid. Crystallisation from ethanol-ether of this hydrochloride gave 0.8 grams (62%) of pale yellow needles, melting point 238.5° C.

후처리

  1. temperatureThe stirred mixture was refluxed for 3 hrs
  2. temperature, then cooled
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-144768edf4944cb4be15329109388f99
출처 데이터셋
uspto-grants-1977_05
특허 번호
US04024147

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