Ammonium Hydroxide → HCID 21432968, 화합물

반응식

[OH-].[NH4+:2].C[O:4][C:5]([C:7]1[CH:12]=[C:11]([Br:13])[C:10]([OH:14])=[C:9]([Br:15])[N:8]=1)=O>>[Br:13][C:11]1[C:10]([OH:14])=[C:9]([Br:15])[N:8]=[C:7]([C:5]([NH2:2])=[O:4])[CH:12]=1

참가 물질

반응물 2

HCID 14923Ammonium Hydroxide

HCID 20674264HCID 20674264, 화합물

생성물 1

HCID 21432968HCID 21432968, 화합물수율 80%

실험 절차

Concentrated ammonium hydroxide, 180 ml, was added to 10 g of 4,6-dibromo-5-hydroxy-2-pyridinecarboxylic acid methyl ester and heated at 45°-60° C. for 1 hour. After the mixture was kept for 2 days at room temperature, the solid was filtered and successively washed with dilute HCl (to neutralize the ammonia) and then with methanol and benzene to remove any unreacted starting material. The product was isolated in 80% yield; m.p. 261-266° C. (best sample: m.p. 275° C.).

후처리

temperatureheated at 45°-60° C. for 1 hour
filtrationthe solid was filtered
washsuccessively washed with dilute HCl (
customto remove
customThe product was isolated in 80% yield

출처 및 근거

ORD 기록: ord-2500c11cac2b4ba094224738a5d04dfc
출처 데이터셋: uspto-grants-1977_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04025333

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