Phosphorus pentachloride → HCID 178479351, 화합물

HRID 2398626노트

반응식

HRID 2398626 반응식
[ClH:1].[C:2]([NH:10][CH2:11][C:12]([OH:14])=O)(=[NH:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:16]>C(Cl)Cl>[ClH:16].[C:2]([NH:10][CH2:11][C:12]([Cl:1])=[O:14])(=[NH:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 24819Phosphorus pentachlorideHCID 178479352HCID 178479352, 화합물

생성물 1

HCID 178479351HCID 178479351, 화합물수율 99%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To benzimidoylaminoacetic acid hydrochloride (2.2 g., 10 mmoles) in 40 ml. of dry methylene chloride is added 2.5 g. (12 mmoles) of phosphorous pentachloride, and the reaction mixture allowed to stir overnight at room temperature. The product is filtered, washed successively with methylene chloride (50 ml. ), chloroform 2× 75 ml.) and hexane (50 ml.) and dried in vacuo, 2.5 g. (99% yield).

후처리

  1. filtrationThe product is filtered
  2. washwashed successively with methylene chloride (50 ml. ), chloroform 2× 75 ml
  3. dry with material) and hexane (50 ml.) and dried in vacuo, 2.5 g

출처 및 근거

ORD 기록
ord-8472ed6ac61a4e67b131e5ed0c83f3cf
출처 데이터셋
uspto-grants-1977_05
특허 번호
US04025506

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