Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyclohexanol → 5-Cyclohexyloxy-2-carbomethoxyaminobenzimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyclohexanol | HCID 7966 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 5-Chloro-2-nitroaniline | HCID 74218 | — |
| 반응물 | Methyl N-cyanocarbamate | HCID 89023 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-Cyclohexyloxy-2-carbomethoxyaminobenzimidazole | HCID 20284434 | — |
반응 단계
A mixture of cyclohexanol (0.03 mol) in 75 ml. of dry dimethylformamide under nitrogen is agitated while 55% sodium hydride (0.03 mol) in oil is added portionwise. When evolution of hydrogen ceases 2-nitro-5-chloroaniline (0.025 mol) is added with stirring. The mixture is warmed at 75°-80° C. for 1 hour then poured onto 6 volumes of ice slurry. The separated product recrystallized from water to give red crystals of the nitroaminobiphenylether. After hydrogenation and reaction with carbomethoxycyanamide as described above the product, 5-cyclohexyloxy-2-carbomethoxyaminobenzimidazole is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04025638 |
| 출처 데이터셋 | uspto-grants-1977_05 |
| ORD ID | ord-1c5f0135e69a40848c0e08e99d8c8114 |
| 출처 메모 | uspto-grants-1977_05 |