Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Fluoro-5-methylphenyl isocyanate → N-(4-bromo-2-ethylphenyl)-N'-(2-fluoro-5-methylphenyl)urea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Fluoro-5-methylphenyl isocyanate | HCID 2733377 | — |
| 반응물 | 4-Bromo-2-ethylaniline | HCID 2801283 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(4-bromo-2-ethylphenyl)-N'-(2-fluoro-5-methylphenyl)urea | HCID 66680634 | 64.7% |
반응 단계
A solution of 4-bromo-2-ethylaniline (200 mg) in dichloromethane (10 mL) was treated with 1-fluoro-2-isocyanato-4-methylbenzene (151 mg), stirred at room temperature overnight, diluted with hexanes, and filtered. The filter cake provided 227 mg of the desired product. MS (ESI(+)) m/e 351,353 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08642776B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-2b6b93845cc1458e9aa075848bbde5c7 |
| 출처 메모 | uspto-grants-2014_02 |